Additional file 1.

Microsoft Excel^® spreadsheet for using Solver or the 3 point method to derive kinetic parameters for the model of approach to steady state. This spreadsheet contains numerical data from the Keys study and was written using Excel 2003. The worksheet with the tab labeled "Model Using Solver" gives instructions for how to obtain parameters for best fit of the data to the equation of approach to steady state. The worksheet labeled "Methods Compared" shows that the 3 point method gives the same estimates for rate parameters as Solver does when data are limited (compare results in cells G2 and G3 with cells L9 and L10). Readers may obtain the values for changes in heart volume and resting energy expenditure by placing the cursor in cell L9 and filling across to cells M9 and N9. Then do the same operation for cells L10 through N10. This operation solves equations 5 and 6 using data for the two endpoints. The method using Solver would be preferred for a study in which data have been collected at frequent intervals.

Format: XLS Size: 62KB Download file

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Hargrove et al. Dynamic Medicine 2008 7:16   doi:10.1186/1476-5918-7-16